Material derived from 1997 Pemberton et al Factor VIII A Domain Paper:
(Alternatively go to the BLOOD website and look up Pemberton et al
, 1997, Vol 89 p2413).
Figure 1a (in ASCII):
FVIII/Cp amino-acid sequence lineup of A1 domain showing SCRs and VRs
Figure 1b (in ASCII):
FVIII/Cp amino-acid sequence lineup of A2 domain showing SCRs and VRs
Figure 1c (in ASCII):
FVIII/Cp amino-acid sequence lineup of A3 domain showing SCRs and VRs
Figure 1d (GIF format):
FVIII/Cp/FV amino-acid sequence lineup of A1 domain from different species showing level of conservation
Figure 1e (GIF format):
FVIII/Cp/FV amino-acid sequence lineup of A2 domain from different species showing level of conservation
Figure 1f (GIF format):
FVIII/Cp/FV amino-acid sequence lineup of A3 domain from different species showing level of conservation
Figure 2 (GIF format)
Homology model of the A domains of FVIII: general views
Figure 3 (GIF format)
Predicted secondary structural features
Figure 4 (GIF format)
Predicted type-II Copper atom placement between A1 and A3 (could be completely wrong!)
Figure 5 (GIF format)
Predicted binding-sites for FIXa and BiP (as understood in 1997 - there are more sites now for FIXa)
Figure 6 (GIF format)
Suggested APC and thrombin binding sites
Figure 7 (GIF format)
Glycosylation variant M1772T
Figure Legends
Alternatively go to the BLOOD website and look up Pemberton et al
, 1997, Vol 89 p2413.
